Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children
Duration: 5 mins
Publication Date: 4 Oct 2022
Next Review Date: 4 Oct 2025
DOI: 10.13056/acamh.21094
Description
In this Video Abstract, Sandra Machlitt-Northen talks about her JCPP paper ‘Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: evidence of gene–environment correlation’. Whilst genetic and environmental risk factors for schizophrenia (SCZ) and major depressive disorder (MDD) have been established, it is unclear whether exposure to environmental risk factors is genetically confounded by passive, evocative or active gene–environment correlation (rGE).
Learning Objectives
1. Investigate whether the genetic risk for schizophrenia (SCZ) and major depressive disorder (MDD) in children is correlated with established environmental and psychosocial risk factors.
2. Explore whether these associations vary between both psychopathologies.
3. Examine whether findings differ across two cohorts which were born 42 years apart.
